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G1046
Sigma
[6]-Gingerol
| Synonym: | 3-Decanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)-, 5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone, 6-Gingerol |
| Linear Formula: | C17H26O4 |
| Molecular Weight: | 294.39 |
Description
| Biochem/physiol Actions | [6]-Gingerol is a bioactive compound found in ginger (Zingiber officinale) with antioxidant activity,1 which functions as an anti-inflammatory and antitumor agent. [6]-Gingerol down regulates proinflammatory cytokine release by macrophages.2 It has been shown to inhibit COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin.3 |
Properties
| storage condition | protect from light |
| under inert gas | |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36/37 |
| RIDADR | UN2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | HE0757000 |
References
| Cited Reference | 1. Aeschbach, R. et al., Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol. Food Chem. Toxicol. 32, 31-36, (1994) |
| 2. Tripathi, S. et al., Ginger and its active ingredient 6-gingerol down regulate pro-inflammatory cytokine release by macrophages. J. Surg. Res. 130, 318, (2006) | |
| 3. Kim, S.O., et al., [6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin. Oncogene 24, 2558-2567, (2005) |
